Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human.
Updated July 19, 2023The liver plays a critical role in both immune defense and tolerance in the body. The liver-resident immune cells (LrICs) determine the immune properties, but the unique composition and heterogeneity of these cells are incompletely understood. Here, we dissect the diversity of LrICs by a comprehensive transcriptomic profiling using unbiased single-cell RNA-sequencing (scRNA-seq). Overall design: 10x genomics was used to measure CD45+ immune cells in healthy human liver and paired spleen and PBMCs from the same donors.
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Atlas
Analysis Portals
NoneProject Label
HumanLiverImmuneCells_GSE125188Species
Homo sapiens
Sample Type
specimens
Anatomical Entity
Organ Part
Unspecified
Selected Cell Types
Disease Status (Specimen)
Unspecified
Disease Status (Donor)
Unspecified
Development Stage
human adult stage
Library Construction Method
10X 3' v2 sequencing
Nucleic Acid Source
single cell
Paired End
falseAnalysis Protocol
optimus_post_processing_v1.0.0, optimus_v4.2.3File Format
Cell Count Estimate
207.0kDonor Count
3